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Vigabatrin-associated brain abnormalities on MRI and other neurological symptoms in patients with West syndrome by Gabriela Reyes Valenzuela; Agustina Crespo; Juan Princich; Lorena Fassulo; Marco Semprino; Adolfo Gallo; Carlos Rugilo; Juan Pociecha; Agustin Calvo; Roberto H. Caraballo is a Medicine article available to read on EtoBox.
What is Vigabatrin-associated brain abnormalities on MRI and other neurological symptoms in patients with West syndrome about?
## Objectives: Report a series of children with west syndrome (ws) treated with vigabatrin (vgb) who developed characteristic mri alterations. in the majority, these adverse events were asymptomatic; however, some of the patients developed movement disorders and acute encephalopathy. ## Methods: This is a retrospective analysis of our epilepsy clinical and eeg database of 288 patients with ws seen between 2014 and 2020. all patients who received vgb alone or with concomitant therapies, such as adrenocorticotropic hormone (acth), high-dose oral corticosteroids, ketogenic diet, valproate, levetiracetam, or topiramate, were evaluated. ## Results: In 44 of 288 patients with ws receiving vgb, mri findings compatible with vgb-associated brain abnormalities were identified; median age at diagnosis was 6.29 months (range, 2 weeks to 11 months). the etiology of ws with vigabatrin-associated brain abnormalities on mri (vabam) was unknown in 22 (52.27%), genetic in seven (15.9%), genetic-structural in three (6.8%), structural malformative in three others (6.8%), and structural acquired in eight patients (18.2%). vigabatrin-associated brain abnormalities on mri was asymptomatic in 25 of 44 pat
Who reads Vigabatrin-associated brain abnormalities on MRI and other neurological symptoms in patients with West syndrome?
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- Author
- Gabriela Reyes Valenzuela; Agustina Crespo; Juan Princich; Lorena Fassulo; Marco Semprino; Adolfo Gallo; Carlos Rugilo; Juan Pociecha; Agustin Calvo; Roberto H. Caraballo
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)