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Overexpression of Osteopontin Is Associated with Intrahepatic Metastasis, Early Recurrence, and Poorer Prognosis of Surgically Resected Hepatocellular Carcinoma by Hung‐Wei Pan; Yueh‐Hsing Ou; Shian‐Yang Peng; Shu‐Hsian Liu; Po‐Lin Lai; Po‐Hwaung Lee; Jin‐Chuan Sheu; Chi‐Ling Chen; Hey‐Chi Hsu is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND Intrahepatic metastasis via portal vein spread is an important feature and a crucial unfavorable prognostic factor of hepatocellular carcinoma (HCC). To identify the molecular factors for tumor progression, the authors used differential display (DD) to analyze aberrant gene expression in HCC. The goal of the current study was to elucidate the clinicopathologic and prognostic significance of osteopontin (OPN) in HCC progression. ## METHODS OPN mRNA levels, which were increased preferentially in HCC in a DD assay and verified with Northern blotting, were measured in 240 surgically removed, unifocal, primary HCCs using the reverse transcription–polymerase chain reaction at the exponential phase. OPN mRNA expression was correlated with clinicopathologic features, particularly portal vein invasion, early tumor recurrence, and prognosis. ## RESULTS Osteopontin mRNA was overexpressed in 133 tumors (55%). The OPN overexpression was associated closely with α‐fetoprotein elevation (__P__ = 0.001), __p53__ mutation (__P__ = 0.021), larger tumors (__P__ = 0.002), high‐grade HCC (__P__ < 0.001), late‐stage HCC (__P__ < 0.001), early tumor recurrence and/or metastasis (

Who reads Overexpression of Osteopontin Is Associated with Intrahepatic Metastasis, Early Recurrence, and Poorer Prognosis of Surgically Resected Hepatocellular Carcinoma?

Author

Hung‐Wei Pan; Yueh‐Hsing Ou; Shian‐Yang Peng; Shu‐Hsian Liu; Po‐Lin Lai; Po‐Hwaung Lee; Jin‐Chuan Sheu; Chi‐Ling Chen; Hey‐Chi Hsu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2003

Language

EN

Field

Medicine (Health Sciences)