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Phase I and II metabolites of speciogynine, a diastereomer of the main Kratom alkaloid mitragynine, identified in rat and human urine by liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry by Anika A. Philipp; Dirk K. Wissenbach; Armin A. Weber; Josef Zapp; Hans H. Maurer is a Chemistry article available to read on EtoBox.

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## Abstract __Mitragyna speciosa__ (__Kratom__ in Thai), a Thai medical plant, is misused as herbal drug of abuse. Besides the most abundant alkaloids mitragynine (MG) and paynantheine (PAY), several other alkaloids were isolated from __Kratom__ leaves, among them the third abundant alkaloid is speciogynine (SG), a diastereomer of MG. The aim of this present study was to identify the phase I and II metabolites of SG in rat urine after the administration of a rather high dose of the pure alkaloid and then to confirm these findings using human urine samples after __Kratom__ use. The applied liquid chromatography coupled to low‐ and high‐resolution mass spectrometry (LC–HRMS‐MS) provided detailed information on the structure in the MS^__n__^ mode particularly with high resolution. For the analysis of the human samples, the LC separation had to be improved markedly allowing the separation of SG and its metabolites from its diastereomer MG and its metabolites. In analogy to MG, besides SG, nine phase I and eight phase II metabolites could be identified in rat urine, but only three phase I and five phase II metabolites in human urine. These differences may be caused by the lower SG dose

Who reads Phase I and II metabolites of speciogynine, a diastereomer of the main Kratom alkaloid mitragynine, identified in rat and human urine by liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry?

Author

Anika A. Philipp; Dirk K. Wissenbach; Armin A. Weber; Josef Zapp; Hans H. Maurer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley-Liss Inc; John Wiley & Sons Inc.; Wiley; Heyden And Son (ISSN 1076-5174)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)