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Cytoskeletal Links of Neuronal Acetylcholine Receptors Containing α7 Subunits by Richard D. Shoop; Naoko Yamada; Darwin K. Berg is a Neuroscience article available to read on EtoBox.

What is Cytoskeletal Links of Neuronal Acetylcholine Receptors Containing α7 Subunits about?

Nicotinic acetylcholine receptors serve a variety of signaling functions in the nervous system depending on cellular location, but little is known about mechanisms responsible for tethering them at specific sites. Among the most interesting are receptors containing the α7 gene product, because of their abundance and high relative permeability to calcium. On chick ciliary ganglion neurons α7-containing receptors are highly concentrated on somatic spines folded into discrete patches on the cell. We show that the spines contain filamentous actin and drebrin. After cell dissociation, the actin slowly redistributes, the spines retract, and the α7-containing receptors disperse and are subsequently lost from the surface. Latrunculin A, a drug that depolymerizes filamentous actin, accelerates receptor dispersal, whereas jasplikinolide, a drug that stabilizes the actin cytoskeleton, preserves large receptor clusters and prevents receptor loss from the surface. The receptors are resistant to extraction by nonionic detergent even after latrunculin A treatment. Other, less abundant, nicotinic receptors on the neurons are readily solubilized by the detergent even though these receptors are loca

Who reads Cytoskeletal Links of Neuronal Acetylcholine Receptors Containing α7 Subunits?

Author

Richard D. Shoop; Naoko Yamada; Darwin K. Berg

Publisher

Society for Neuroscience (ISSN 0270-6474)

Published

2000

Language

EN

Field

Neuroscience (Life Sciences)