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Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein by Cordaro, Marika; Fusco, Roberta; DâAmico, Ramona; Siracusa, Rosalba; Peritore, Alessio Filippo; Gugliandolo, Enrico; Genovese, Tiziana; Crupi, Rosalia; Mandalari, Giuseppina; Cuzzocrea, Salvatore; Di Paola, Rosanna; Impellizzeri, Daniela is a Medicine article available to read on EtoBox.

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Background: One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3), has not been fully elucidated. Methods: To investigate the effect of cashew (Anacardium occidentale L.) nuts on pancreatic and lung injury induced by cerulein injection, cerulein (50 μg/kg) was administered to CD1 mice for 10 h. Oral treatment with cashew nuts at a dose of 100 mg/kg was given 30 min and 2 h after the first cerulein injection. One hour after the final cerulein injection, mice were euthanized and blood, lung and pancreatic tissue samples were collected. Results: Cashew nuts were able to (1) reduce histological damage; (2) mitigate the induction of mast cell degranulation as well as the activity of myeloperoxidase and malondialdehyde; (3) decrease the activity levels of amylase and lipase as well as the levels of pro-inflammatory

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Author

Cordaro, Marika; Fusco, Roberta; DâAmico, Ramona; Siracusa, Rosalba; Peritore, Alessio Filippo; Gugliandolo, Enrico; Genovese, Tiziana; Crupi, Rosalia; Mandalari, Giuseppina; Cuzzocrea, Salvatore; Di Paola, Rosanna; Impellizzeri, Daniela

Publisher

MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI AG, 2012- (ISSN 2076-3921)

Published

2020

Language

EN

Field

Medicine (Health Sciences)