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Can I read Association of volumetric MRI measures and disability in MS patients of the same age: Descriptions from a birth year cohort on EtoBox?
Association of volumetric MRI measures and disability in MS patients of the same age: Descriptions from a birth year cohort by Lodewijk R.J. de Ruiter; Floor C. Loonstra; Julia R. Jelgerhuis; Eline M.E. Coerver; Alyssa A. Toorop; Ilona C.E. van Leeuwen; Samantha Noteboom; Bastiaan Moraal; Eva M.M. Strijbis; Menno M. Schoonheim; Bernard M.J. Uitdehaag is a Medicine article available to read on EtoBox.
What is Association of volumetric MRI measures and disability in MS patients of the same age: Descriptions from a birth year cohort about?
Background and objectives Although MRI-based markers of neuroinflammation have proven crucial for the diagnosis of multiple sclerosis (MS), predicting clinical progression with inflammation remains difficult. Neurodegenerative markers such as brain volume loss show stronger clinical (predictive) correlations, but also harbor age-related variation that must be disentangled from disease duration. In this study we investigated how clinical disability is related to volumetric MRI measures in a cohort of MS patients and healthy controls (HC) of the same age: Project Y. Methods This study included 234 MS patients born in 1966 and 112 HC born between 1965 and 1967 in the Netherlands. Disability was quantified using the expanded disability status scale (EDSS), nine hole peg test (9HPT), and timed 25 foot walking test (T25FWT). Volumes were quantified on 3T MRI as normalized whole brain (NBV) and regional gray matter (GM) volumes using the same scanner and MRI protocol: cortical (normalized cortical gray matter volume; NCGMV), deep (NDGMV), thalamic (NThalV), and cerebellar (NCbV) GM volumes. In addition, mean upper cervical cord area (MUCCA), white matter lesion volume (LV), and spinal cor
Who reads Association of volumetric MRI measures and disability in MS patients of the same age: Descriptions from a birth year cohort?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lodewijk R.J. de Ruiter; Floor C. Loonstra; Julia R. Jelgerhuis; Eline M.E. Coerver; Alyssa A. Toorop; Ilona C.E. van Leeuwen; Samantha Noteboom; Bastiaan Moraal; Eva M.M. Strijbis; Menno M. Schoonheim; Bernard M.J. Uitdehaag
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)