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Association of cellular HIV-1 DNA and virological success of antiretroviral treatment in HIV-infected sub-Saharan African adults by Moh, Desmorys Raoul (author);Ntakpé, Jean-Baptiste (author);Gabillard, Delphine (author);Yayo-Emieme, Arlette Ahoubet (author);Badjé, Anani (author);Kouame, Gérard M. (author);d’Aquin, Toni Thomas (author);Danel, Christine (author);Anglaret, Xavier (author);Eholié, Serge P. (author) is a Medicine article available to read on EtoBox.
What is Association of cellular HIV-1 DNA and virological success of antiretroviral treatment in HIV-infected sub-Saharan African adults about?
## Abstract ## Background HIV-1 DNA persists in infected cells, forming viral reservoirs. Pre-antiretroviral treatment (ART) HIV-1 DNA load was reported to predict ART success in European severely immunocompromised patients. The aim of this study was to determine whether HIV-1 DNA levels are associated with virological success in less severely immunocompromised patients who receive early ART in sub-Saharan Africa. ## Methods The association between pre-ART HIV-1 DNA and the virological response after 30 months on ART was studied in multivariate logistic regression in patients randomised to immediate ART groups in the Temprano trial, which assessed the benefits of early ART in HIV-infected adults in Côte d’Ivoire. HIV-1 DNA was quantified in peripheral blood mononuclear cell (PBMC) using real-time PCR. ## Results HIV-1 DNA levels were measured in 1013 patients. Their medians [IQR] of pre-ART CD4 count, HIV-1 RNA and HIV-1 DNA levels were 465 [379–578]/mm^3^, 4.7 [4.0–5.3] log~10~ copies/ml and 2.9 [2.5–3.2] log~10~ copies/million PBMC, respectively. Pre-ART HIV-1 DNA was significantly correlated with pre-ART HIV-1 RNA (R = 0.59, p < 0.0001). In multivariate analysis, HIV-1 DNA < 3 l
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- Author
- Moh, Desmorys Raoul (author);Ntakpé, Jean-Baptiste (author);Gabillard, Delphine (author);Yayo-Emieme, Arlette Ahoubet (author);Badjé, Anani (author);Kouame, Gérard M. (author);d’Aquin, Toni Thomas (author);Danel, Christine (author);Anglaret, Xavier (author);Eholié, Serge P. (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)