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15-Year Subthalamic Deep Brain Stimulation outcome in a Parkinson’s disease patient with Parkin gene mutation: a case report by Anna Covolo; Gabriele Imbalzano; Carlo Alberto Artusi; Elisa Montanaro; Claudia Ledda; Marco Bozzali; Mario Giorgio Rizzone; Maurizio Zibetti; Tiziana Martone; Leonardo Lopiano; Alberto Romagnolo is a Medicine article available to read on EtoBox.
What is 15-Year Subthalamic Deep Brain Stimulation outcome in a Parkinson’s disease patient with Parkin gene mutation: a case report about?
Introduction Parkinson's Disease (PD) patients with Parkin gene (PRKN) mutations show good response to subthalamic deep brain stimulation (STN-DBS). Currently, the longest follow-up available of these patients is 6 years. We report a very long-term outcome (more than 15 years) of a STN-DBS-treated patient with a compound heterozygous deletion of exons 3 and 11 of the PRKN gene. Case report In 1993, a 39-year-old male was diagnosed with PD after the onset of resting tremor. Levodopa was started, and during the following 10 years, he reported good motor symptoms control, with only mild modification of levodopa intake and pramipexole introduction. In 2005, he developed disabling motor fluctuations and dyskinesia. In 2007, he underwent bilateral STN-DBS, with a marked improvement of motor symptoms and fluctuations during the following years. After 6 years, he reported mild motor fluctuations, improved after stimulation and treatment modifications. After 10 years he showed diphasic dyskinesias, feet dystonia, postural instability, and gambling (resolved after pramipexole discontinuation). In 2018, he developed a non-amnestic single-domain mild cognitive impairment (MCI). In 2023, after
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- Author
- Anna Covolo; Gabriele Imbalzano; Carlo Alberto Artusi; Elisa Montanaro; Claudia Ledda; Marco Bozzali; Mario Giorgio Rizzone; Maurizio Zibetti; Tiziana Martone; Leonardo Lopiano; Alberto Romagnolo
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)