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Natural products as sources of new fungicides (V): Design and synthesis of acetophenone derivatives against phytopathogenic fungi in vitro and in vivo by Wen-Jia Dan; Thi-Mai-Luong Tuong; Da-Cheng Wang; Ding Li; An-Ling Zhang; Jin-Ming Gao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Natural products as sources of new fungicides (V): Design and synthesis of acetophenone derivatives against phytopathogenic fungi in vitro and in vivo about?

A series of acetophenone derivatives (10a-10i, 11, 12a-12g, 13a-13g, 14a-14d and 15a-15l) were designed, synthesized and evaluated for antifungal activities in vitro and in vivo. The antifungal activities of 53 compounds were tested against several plant pathogens, and their structure-activity relationship was summarized. Compounds 10a-10f displayed better antifungal effects than two reference fungicides. Interestingly, the most potent compound 10d exhibited antifungal properties against Cytospora sp., Botrytis cinerea, Magnaporthe grisea, with IC 50 values of 6.0-22.6 μg/mL, especially Cytospora sp. (IC 50 = 6.0 μg/mL). In the in vivo antifungal assays, 10d displayed the significant protective efficacy of 55.3% to Botrytis cinerea and 73.1% to Cytospora sp. The findings indicated that 10d may act as a potential pesticide lead compound that merits further investigation.

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Author

Wen-Jia Dan; Thi-Mai-Luong Tuong; Da-Cheng Wang; Ding Li; An-Ling Zhang; Jin-Ming Gao

Publisher

Elsevier BV

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)