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Pharmacokinetic Assessment of an Oral Enalapril Suspension for Use in Children by Ronda K. Rippley; John Connor; Janet Boyle; Thomas E Bradstreet; Elizabeth Hand; Man-Wai Lo; M. Gail Murphy is a Medicine article available to read on EtoBox.

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## Abstract The angiotensin‐converting enzyme (ACE) inhibitor enalapril is commonly used to treat pediatric hypertension__.__ Because some children are unable to swallow tablets or require doses less than the lowest available enalapril tablet, an enalapril suspension was developed. This study examined the relative bioavailability of enalapril suspension (10 mg) (S) compared with 10‐mg marketed VASOTECTM tablets (T) in 16 healthy adult subjects. The geometric mean ratio (S/T) estimate of urinary recovery of free enalaprilat, the active moiety, was 0.92 (90% confidence interval (CI): 0.80, 1.07). Urinary recovery data indicate that approximately 50% of the dose was absorbed (50% recovered in urine as enalapril plus enalaprilat) with about 30% of the dose recovered as free enalaprilat for both S and T. The geometric mean ratios (S/T) of serum AUC and __C__~max~ were 1.01 (90% CI: 0.90, 1.13) and 0.98 (90% CI: 0.83, 1.16), respectively. Suspension __T__~max~ was slightly shorter (0.5 h) than that for tablet, but this difference is not clinically significant. Both formulations were well tolerated and there were no clinically significant adverse experiences. We conclude that the bioavail

Who reads Pharmacokinetic Assessment of an Oral Enalapril Suspension for Use in Children?

Author

Ronda K. Rippley; John Connor; Janet Boyle; Thomas E Bradstreet; Elizabeth Hand; Man-Wai Lo; M. Gail Murphy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0142-2782)

Published

2000

Language

EN

Field

Medicine (Health Sciences)