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Association Between Creatinine-adjusted and Unadjusted Urine Cotinine Values in Children and the Mother's Report of Exposure to Environmental Tobacco Smoke by Peter A. Fried; Sherry L. Perkins; Barbara Watkinson; Joel S. McCartney is a Medicine article available to read on EtoBox.

What is Association Between Creatinine-adjusted and Unadjusted Urine Cotinine Values in Children and the Mother's Report of Exposure to Environmental Tobacco Smoke about?

Objective: To examine the association between parents' report of their child's secondhand smoke exposure and various adjustments of cotinine concentrations in random urine samples. Methods: Urine cotinine and creatinine were measured in 109 six to 11-year-old children from predominantly upper middleclass families. Cotinine values were considered as: (a) unadjusted, (b) as a cotinine/creatinine ratio, (c) as adjusted based on a regression relationship between cotinine and creatinine, and (d) and (e) as a cotinine/creatinine ratio adjusted for age and sex. Results: Little overlap in cotinine values occurred between exposed and nonexposed children, and a dose-response relationship was noted between the parental report and the urine cotinine values (r = 0.67). A modest improvement occurred in the correlation when the cotinine/creatinine ratio was considered. Considering exposure to cigarette smoke outside the home as well as in the household only improved the correlation when the former exposure was heavy. A high degree of concordance exists between the parents' report of exposure and the child's urine cotinine. Conclusions: The value of adjusting this biochemical parameter by various

Who reads Association Between Creatinine-adjusted and Unadjusted Urine Cotinine Values in Children and the Mother's Report of Exposure to Environmental Tobacco Smoke?

Author

Peter A. Fried; Sherry L. Perkins; Barbara Watkinson; Joel S. McCartney

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

1995

Language

EN

Field

Medicine (Health Sciences)