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What is Amino Acid Conjugation Pathways about?

This document provides an overview of amino acid conjugation pathways, detailing how xenobiotics with carboxylic or aromatic hydroxylamine groups can conjugate with amino acids. It describes the activation of amino acids by aminoacyl-tRNA-synthetase and the formation of reactive N-esters that can lead to electrophilic ions. Additionally, it mentions the conjugation of carboxylic acids with coenzyme A to produce clinically relevant amide-linked conjugates.

Author

Gabriel Prabowo

Language

EN