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Membrane and Soluble Endoglin Role in Cardiovascular and Metabolic Disorders Related to Metabolic Syndrome by Matej Vicen; Ivone Cristina Igreja Sá; Katarína Tripská; Barbora Vitverová; Iveta Najmanová; Samira Eissazadeh; Stanislav Micuda; Petr Nachtigal is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Membrane and Soluble Endoglin Role in Cardiovascular and Metabolic Disorders Related to Metabolic Syndrome about?
Membrane endoglin (Eng, CD105) is a transmembrane glycoprotein essential for the proper function of vascular endothelium. It might be cleaved by matrix metalloproteinases to form soluble endoglin (sEng), which is released into the circulation. Metabolic syndrome comprises conditions/symptoms that usually coincide (endothelial dysfunction, arterial hypertension, hyperglycemia, obesity-related insulin resistance, and hypercholesterolemia), and are considered risk factors for cardiometabolic disorders such as atherosclerosis, type II diabetes mellitus, and liver disorders. The purpose of this review is to highlight current knowledge about the role of Eng and sEng in the disorders mentioned above, in vivo and in vitro extent, where we can find a wide range of contradictory results. We propose that reduced Eng expression is a hallmark of endothelial dysfunction development in chronic pathologies related to metabolic syndrome. Eng expression is also essential for leukocyte transmigration and acute inflammation, suggesting that Eng is crucial for the regulation of endothelial function during the acute phase of vascular defense reaction to harmful conditions. sEng was shown to be a circula
Who reads Membrane and Soluble Endoglin Role in Cardiovascular and Metabolic Disorders Related to Metabolic Syndrome?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Matej Vicen; Ivone Cristina Igreja Sá; Katarína Tripská; Barbora Vitverová; Iveta Najmanová; Samira Eissazadeh; Stanislav Micuda; Petr Nachtigal
- Publisher
- Springer; Springer-Verlag; Birkhauser Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1420-682X)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)