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Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin by Laure Janot; Jean-Claude Sirard; Thomas Secher; Nicolas Noulin; Lizette Fick; Shizuo Akira; Satoshi Uematsu; Arnaud Didierlaurent; Tracy Hussell; Bernhard Ryffel; Francois Erard is a Immunology and Microbiology article available to read on EtoBox.
What is Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin about?
## Abstract Bacterial products (such as endotoxins and flagellin) trigger innate immune responses through TLRs. Flagellin‐induced signalling involves TLR5 and MyD88 and, according to some reports, TLR4. Whereas epithelial and dendritic cells are stimulated by flagellin __in vitro__, the cell contribution to the __in vivo__ response is still unclear. Here, we studied the respective roles of radioresistant and radiosensitive cells in flagellin‐induced airway inflammation in mice. We found that i.n. delivery of flagellin elicits a transient change in respiratory function and an acute, pro‐inflammatory response in the lungs, characterized by TLR5‐ and MyD88‐dependent chemokine secretion and neutrophil recruitment. In contrast, TLR4, CD14 and TRIF were not essential for flagellin‐mediated responses, indicating that TLR4 does not cooperate with TLR5 in the lungs. Respiratory function, chemokine secretion and airway infiltration by neutrophils were dependent on radioresistant, TLR5‐expressing cells. Furthermore, lung haematopoietic cells also responded to flagellin by activating TNF‐α production. We suggest that the radioresistant lung epithelial cells are essential for initiating early,
Who reads Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Laure Janot; Jean-Claude Sirard; Thomas Secher; Nicolas Noulin; Lizette Fick; Shizuo Akira; Satoshi Uematsu; Arnaud Didierlaurent; Tracy Hussell; Bernhard Ryffel; Francois Erard
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)
- Published
- 2009
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)