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Bioavailability of oral vs. subcutaneous low-dose methotrexate in patients with Crohn's disease by D. Kurnik; R. Loebstein; E. Fishbein; S. Almog; H. Halkin; S. Bar-Meir; Y. Chowers is a Medicine article available to read on EtoBox.
What is Bioavailability of oral vs. subcutaneous low-dose methotrexate in patients with Crohn's disease about?
## Summary **Background** : Oral methotrexate and folic acid are partly absorbed by a common intestinal transporter. **Aim** : To determine the relative bioavailability of oral low‐dose methotrexate administered with and without concomitant folic acid vs. subcutaneous administration in patients with stable Crohn's disease. **Methods** : Ten patients were randomized to receive their regular maintenance dose of methotrexate (15–25 mg) for three consecutive weeks: orally, orally with 5 mg folic acid or subcutaneously. Blood samples were drawn at specified intervals during 24 h, and methotrexate levels were determined by fluorescence immunoassay. Areas under the curve extrapolated to infinity (__AUC__~∞~) were compared between the three routes. **Results** : The geometric mean __AUC__~∞~ values (95% confidence intervals) were 360 nmol.h/L (301–430 nmol.h/L), 261 nmol.h/L (214–318 nmol.h/L) and 281 nmol.h/L (209–377 nmol.h/L) per milligram of methotrexate administered for subcutaneous, oral and oral with folic acid administration, respectively (__P__ < 0.05 and __P__ < 0.01 for oral with folic acid and oral vs. subcutaneous administration, respectively). The geometric mean relative bioa
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- Author
- D. Kurnik; R. Loebstein; E. Fishbein; S. Almog; H. Halkin; S. Bar-Meir; Y. Chowers
- Publisher
- John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)