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Acute lymphocytic leukemia: Biological markers of clinical response by Alvin M. Mauer; W. Paul Bowman; Lois W. Dow; A. Thomas Look; Dorothy Williams is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Acute lymphocytic leukemia: Biological markers of clinical response about?

Treatment for acute lymphocytic leukemia (ALL) has been successful in producing cures for some children with that disease. It has become increasingly important therefore to develop treatment regimens for curable ALL that are effective for disease control but carry minimal risks of late detrimental consequences. For other children current therapy i s still inadequate and treatment failure occurs. For these children altered treatment strategy must be developed that includes intensification of some treatment components, since improved methods of disease control are the primary consideration. In this paper the clinical and laboratory methods by which risk groups can be defined at diagnosis have been described. We have increasingly effective means by which the expected treatment outcome with current therapy can be defined at diagnosis. This assignment to a specific risk group is important to provide children with ALL with the most appropriate therapy for their expected clinical response. These studies of clinical utility also pose biological questions concerning the relationship of such things as white blood count, leukemic cell karyotype, and initial proliferative activity to the likel

Who reads Acute lymphocytic leukemia: Biological markers of clinical response?

Author

Alvin M. Mauer; W. Paul Bowman; Lois W. Dow; A. Thomas Look; Dorothy Williams

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1982

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)