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Evaluation of the Endometrial Receptivity Assay and the Preimplantation Genetic Test for Aneuploidy in Overcoming Recurrent Implantation Failure by Mauro Cozzolino; Patricia Diaz-Gimeno; Antonio Pellicer; Nicolas Garrido is a Medicine article available to read on EtoBox.

What is Evaluation of the Endometrial Receptivity Assay and the Preimplantation Genetic Test for Aneuploidy in Overcoming Recurrent Implantation Failure about?

## Purpose: To evaluate the clinical usefulness of the endometrial receptivity array (era) and the preimplantation genetic test for aneuploidy (pgt-a) in patients with severe and moderate recurrent implantation failure (rif). ## Design: A retrospective multicenter cohort study was conducted in patients who failed to achieve implantation following transfer of 3 or more or 5 or more embryos in at least three single embryo transfers; patients were classified as moderate or severe rif, respectively. patients with previous rif were compared based on the testing they received: pgt-a, era, or pgt-a+era versus a control group with no testing. mean implantation rate and ongoing pregnancy rates per embryo transfer were considered primary outcomes. multiple logistic regression analysis was performed and adjusted ors were calculated to control possible bias. ## Results: Of the 2110 patients belonging to the moderate rif group, those who underwent transfer of euploid embryos after pgt-a had a higher implantation rate than those who did not. additionally, the pgt-a group had a significantly higher rate of ongoing pregnancy. the same outcomes measured for the 488 patients in the severe rif group

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Author

Mauro Cozzolino; Patricia Diaz-Gimeno; Antonio Pellicer; Nicolas Garrido

Publisher

Springer Science and Business Media LLC

Published

2020

Language

EN

Field

Medicine (Health Sciences)