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Dpp Regulates Autophagy-dependent Midgut Removal and Signals to Block Ecdysone Production by Donna Denton; Tianqi Xu; Sonia Dayan; Shannon Nicolson; Sharad Kumar is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Dpp Regulates Autophagy-dependent Midgut Removal and Signals to Block Ecdysone Production about?

Animal development and homeostasis require the programmed removal of cells. Autophagy-dependent cell deletion is a unique form of cell death often involved in bulk degradation of tissues. In Drosophila the steroid hormone ecdysone controls developmental transitions and triggers the autophagy-dependent removal of the obsolete larval midgut. The production of ecdysone is exquisitely coordinated with signals from numerous organ systems to mediate the correct timing of such developmental programs. Here we report an unexpected role for the Drosophila bone morphogenetic protein/transforming growth factor β ligand, Decapentaplegic (Dpp), in the regulation of ecdysone-mediated midgut degradation. We show that blocking Dpp signaling induces premature autophagy, rapid cell death, and midgut degradation, whereas sustained Dpp signaling inhibits autophagy induction. Furthermore, Dpp signaling in the midgut prevents the expression of ecdysone responsive genes and impairs ecdysone production in the prothoracic gland. We propose that Dpp has dual roles: one within the midgut to prevent improper tissue degradation, and one in interorgan communication to coordinate ecdysone biosynthesis and develop

Who reads Dpp Regulates Autophagy-dependent Midgut Removal and Signals to Block Ecdysone Production?

Author

Donna Denton; Tianqi Xu; Sonia Dayan; Shannon Nicolson; Sharad Kumar

Publisher

Nature Publishing Group; Springer Science and Business Media LLC (ISSN 1350-9047)

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)