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Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: A case‐control study in Japanese nonsmoking women by Chikako Kiyohara; Kenji Wakai; Haruo Mikami; Koichi Sido; Masahiko Ando; Yoshiyuki Ohno is a Medicine article available to read on EtoBox.
What is Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: A case‐control study in Japanese nonsmoking women about?
## Abstract Genetic backgrounds may modify the association of environmental tobacco smoke (ETS) with lung cancer risk. Polymorphisms of both the activating and detoxifying enzymes, cytochrome P4501A1 (CYP1A1) and glutathione‐S‐transferase M1 (GSTM1), may be important as genetic factors. We conducted a multicenter case‐control study in Japanese nonsmoking women. Cases were women aged 30–89 years and newly diagnosed as having lung cancer from November 1997 to March 2001 in 4 study areas. We also recruited age‐matched (5‐year strata) and hospital‐matched nonsmoking controls. A total of 158 cases and 259 hospital controls supplied blood for genotyping. Detailed information on ETS exposure from husbands and that in other situations and on potential confounders was collected by interview. Odds ratios (ORs) were estimated by using conditional logistic models. We found no increase in the risk of lung cancer for __CYP1A1 Msp__ I genotypes. For the __GSTM1__ null genotype __vs.__ nonnull genotype, the OR was 1.37 [95% confidence interval (CI) 0.90–2.09], which indicated a somewhat increased risk for the __GSTM1__ null genotype. A gene‐environment interaction was suggested, with combined __GS
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It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Chikako Kiyohara; Kenji Wakai; Haruo Mikami; Koichi Sido; Masahiko Ando; Yoshiyuki Ohno
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)