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The Growth Feature and Its Diagnostic Value for Benign and Malignant Pulmonary Nodules Met in Routine Clinical Practice by Rui Zhang; Panwen Tian; Zhixin Qiu; Yiying Liang; Weimin Li is a Medicine article available to read on EtoBox.

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## Background Growth rate is an independent risk factor for lung cancer in screened pulmonary nodules. This study aimed to clarify growth characteristics of pulmonary nodules in routine clinical practice and examine whether volume doubling time (VDT) can predict the malignancy of these nodules. ## Methods We retrospectively enrolled patients with 5–30-mm-sized pulmonary nodules that had been surgically resected after a follow-up of at least 3 months. Two follow-up computed tomography (CT) images with similar thickness and long interval were obtained. Then, three-dimensional (3D) manual segmentation for all nodules was performed on two follow-up CT scans. Subsequently, VDT was calculated for nodules with a change in volume of at least 25%. ## Results Overall, 305 pulmonary nodules in 305 patients (men, 36.7%; median age, 57) were included. The mean increased diameter, mass, and volume of benign (n=86) and malignant (n=219) nodules were 0.09 __vs.__ 2.37 mm, 0.10 __vs.__ 0.66 g, and 32.74 __vs.__ 1,871.28 mm3, respectively (P<0.05). In total, 24 of 86 benign nodules (28%, 18 grew and 6 shrank) and 121 of 219 malignant nodules (55%, 114 grew and 7 shrank) changed over time. The median

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Author

Rui Zhang; Panwen Tian; Zhixin Qiu; Yiying Liang; Weimin Li

Publisher

AME Publishing Company; Hong Kong: Pioneer Bioscience Publishing Company (ISSN 2072-1439)

Published

2020

Language

EN

Field

Medicine (Health Sciences)