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Avian Photogenic Epilepsy and Embryonic Brain Chimeras: Neuronal Activity of the Adult Prosencephalon and Mesencephalon by N. T. M. Guy; C. Batini; R. Naquet; M A Teillet is a Neuroscience article available to read on EtoBox.

What is Avian Photogenic Epilepsy and Embryonic Brain Chimeras: Neuronal Activity of the Adult Prosencephalon and Mesencephalon about?

Photogenic genetic epilepsy was studied in an avian model, using either the Fayoumi epileptic chicken (Fepi) or neural chimeras obtained by replacement of embryonic brain vesicles in normal chickens with those of Fepi embryos. In these two kinds of animals motor seizures accompanied by electroencephalographic (EEG) desynchronization and flattening (DF) were evoked by intermittent light stimulation (ILS). In chimeras with only the prosencephalon grafted, motor seizures were less severe but DF remained. ILS-induced DF persisted under paralysis by gallamine triethiodide (Flaxedil). Extracellular recordings were made in the prosencephalon (wulst) and in the mesencephalon (optic tectum) of paralysed animals. Units recorded in the prosencephalon of Fepi and chimeras showed abnormal interictal bursting activity, distinctly different from the non-epileptic Fayoumi heterozygotes (Fhtz) and normal chickens. The mesencephalic units of Fepi and chimeras having both prosencephalon and mesencephalon grafted showed two types of abnormal activities during ILS-induced DF, which were distinct from the non-epileptic chickens: type I neurons displaying early, high sensitivity to ILS followed by a prol

Who reads Avian Photogenic Epilepsy and Embryonic Brain Chimeras: Neuronal Activity of the Adult Prosencephalon and Mesencephalon?

Author

N. T. M. Guy; C. Batini; R. Naquet; M A Teillet

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0014-4819)

Published

1993

Language

EN

Field

Neuroscience (Life Sciences)