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Can I read Evidence for Delivery of Abraxane via a Denatured-Albumin Transport System on EtoBox?
Evidence for Delivery of Abraxane via a Denatured-Albumin Transport System by Maichi Hama; Yu Ishima; Victor Tuan Giam Chuang; Hidenori Ando; Taro Shimizu; Tatsuhiro Ishida is a Engineering article available to read on EtoBox.
What is Evidence for Delivery of Abraxane via a Denatured-Albumin Transport System about?
Abraxane, an albumin-bound paclitaxel nanoparticle formulation, is superior to conventional paclitaxel preparations because it has better efficacy against unresectable pancreatic cancer. Previous reports suggest that this better efficacy of Abraxane than conventional paclitaxel preparation is probably due to its transport through Gp60, an albumin receptor on the surface of vascular endothelial cells. The increased tumor accumulation of Abraxane is also caused by the secreted protein acid and rich in cysteine in the tumor stroma. However, the uptake mechanism of Abraxane remains poorly understood. In this study, we demonstrated that the delivery of Abraxane occurred via different receptor pathways from that of endogenous albumin. Our results showed that the uptake of endogenous albumin was inhibited by a Gp60 pathway inhibitor in the process of endocytosis through endothelial cells or tumor cells. In contrast, the uptake of Abraxane-derived HSA was less affected by the Gp60 pathway inhibitor but significantly reduced by denatured albumin receptor inhibitors. In conclusion, these data indicate that Abraxane-derived HSA was taken up into endothelial cells or tumor cells by a mechanism
Who reads Evidence for Delivery of Abraxane via a Denatured-Albumin Transport System?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Maichi Hama; Yu Ishima; Victor Tuan Giam Chuang; Hidenori Ando; Taro Shimizu; Tatsuhiro Ishida
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)