Can I read Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy on EtoBox?

Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy by Timofeev, Oleg (author);Stiewe, Thorsten (author) is a Medicine article available to read on EtoBox.

What is Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy about?

## Simple Summary p53 is a DNA-binding protein that activates hundreds of genes, which act concertedly to suppress the development, expansion, and spreading of cancer cells. The remarkable tumor suppressive activity relies on p53′s ability to bind DNA not as a single molecule, but in a cooperative manner as a complex of four tightly interacting proteins. We describe the structural features of p53 that enable DNA binding cooperativity and review the implications for p53 function. In approximately 50% of cancers, p53 is inactivated by mutations that either distort the 3D structure of the protein or destroy points of DNA contact. In this review, we emphasize that an estimated number of 34,000 cancer cases annually are caused by a third class of so-called “cooperativity” mutations, which selectively compromise the cooperative nature of DNA binding. We highlight the unique characteristics of tumors with p53 cooperativity mutations and discuss personalized treatment options for these cancer patients. ## Abstract p53 is a tumor suppressor that is mutated in half of all cancers. The high clinical relevance has made p53 a model transcription factor for delineating general mechanisms of tran

Who reads Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy?

Author

Timofeev, Oleg (author);Stiewe, Thorsten (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)