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Exploring Cardiac Macrophage Heterogeneity in the Healthy and Diseased Myocardium by Rysa Zaman; Homaira Hamidzada; Slava Epelman is a Immunology and Microbiology article available to read on EtoBox.

What is Exploring Cardiac Macrophage Heterogeneity in the Healthy and Diseased Myocardium about?

Cardiac macrophages maintain homeostasis and orchestrate response to disease. Utilization of genetic fate-mapping and single-cell RNA sequencing shifted the paradigm of macrophage heterogeneity from the canonical M1/M2 classification in favour of a nuanced approach that reconciles divergent origins, lifecycles, and transcriptional states. Here, we provide a conceptual framework to assess cardiac macrophage complexity that integrates transcriptional and functional heterogeneity that tracks with subset-specific markers (TIMD4 and CCR2). Our goal is to provide a starting point for researchers to dissect the functions of known resident cardiac macrophage subpopulations. We discuss recent advances and limitations in our understanding of cardiac macrophage diversity in ischemic injury, hypertension and myocarditis.

Who reads Exploring Cardiac Macrophage Heterogeneity in the Healthy and Diseased Myocardium?

Author

Rysa Zaman; Homaira Hamidzada; Slava Epelman

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Immunology and Microbiology (Life Sciences)