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Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers by Zhao, Jie; Pan, Xiangqiang; Zhu, Jian; Zhu, Xiulin is a Materials Science article available to read on EtoBox.

What is Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers about?

Stimuli-responsive functional gels have shown significant potential for application in biosensing and drug release systems. In this study, aggregation-induced emission luminogen (AIEgen)-functionalized, diselenide-crosslinked polymer gels were synthesized via free radical copolymerization. A series of polymer gels with different crosslink densities or tetraphenylethylene (TPE) contents were synthesized. The diselenide crosslinker in the gels could be fragmented in the presence of H~2~O~2~ or dithiothreitol (DTT) due to its redox-responsive property. Thus, the TPE-containing polymer chains were released into the aqueous solution. As a result, the aqueous solution exhibited enhanced fluorescence emission due to the strong hydrophobicity of TPE. The degradation of polymer gels and fluorescence enhancement in an aqueous solution under different H~2~O~2~ or DTT concentrations were studied. Furthermore, the polymer gels could be used as drug carriers, suggesting a visual drug release process under the action of external redox agents. The AIEgen-functionalized, diselenide-crosslinked polymer gels hold great potential in the biomedical area for biosensing and controlled drug delivery.

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Author

Zhao, Jie; Pan, Xiangqiang; Zhu, Jian; Zhu, Xiulin

Publisher

MDPI AG; MDPI Open Access Publishing; Basel: Molecular Diversity Preservation International (MDPI), 2009- (ISSN 2073-4360)

Published

2020

Language

EN

Field

Materials Science (Physical Sciences)