Can I read Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus on EtoBox?

Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus by Belén Torres; Francisco Aguilar; Ernesto Franco; Elena Sánchez; Julio Sánchez‐Román; Juan Jiménez Alonso; Antonio Núñez‐Roldán; Javier Martín; María Francisca González‐Escribano is a Medicine article available to read on EtoBox.

What is Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus about?

## Objective. To investigate the possible association of the CT60A/G marker with systemic lupus erythematosus (SLE) in Spanish patients, and to identify the possible CTLA4 haplotype responsible for the association, taking into account other polymorphisms described at positions ؊1722T/C, ؊319C/T, ؉49A/G, and the microsatellite (AT) n in the 3-untranslated region (3-UTR) of the CTLA4 gene. Methods. Genotyping of CT60 was performed in 395 patients with SLE and 293 healthy controls using polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis. Genotyping of the rest of the dimorphisms has been previously reported. Genotyping of microsatellite polymorphism (AT) n in the 3-UTR was performed using PCR with a fluorescencelabeled primer. Results. With regard to CT60A/G, the frequency of the AA genotype was significantly decreased among the SLE patients (18.7% versus 28.3% in the control group; P ‫؍‬ 0.003, corrected P [P corr ] ‫؍‬ 0.009, odds ratio [OR] ‫؍‬ 0.58, 95% confidence interval [95% CI] 0.40-0.85). In other words, the frequency of individuals bearing the G phenotype was increased in the patient group compared with the control group (81.2% versus 71.7%; P

Who reads Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus?

Author

Belén Torres; Francisco Aguilar; Ernesto Franco; Elena Sánchez; Julio Sánchez‐Román; Juan Jiménez Alonso; Antonio Núñez‐Roldán; Javier Martín; María Francisca González‐Escribano

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)

Published

2004

Language

EN

Field

Medicine (Health Sciences)