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c‐MYC activation impairs the NF‐κB and the interferon response: Implications for the pathogenesis of Burkitt's lymphoma by Martin Schlee; Michael Hölzel; Sandra Bernard; Reinhard Mailhammer; Marino Schuhmacher; Judith Reschke; Dirk Eick; Dragan Marinkovic; Thomas Wirth; Andreas Rosenwald; Louis M. Staudt; Martin Eilers; Fanny Baran‐Marszak; Remi Fagard; Jean Feuillard; Gerhard Laux; Georg W. Bornkamm is a Medicine article available to read on EtoBox.
What is c‐MYC activation impairs the NF‐κB and the interferon response: Implications for the pathogenesis of Burkitt's lymphoma about?
## Abstract Deregulation of the proto‐oncogene __c‐myc__ is a key event in the pathogenesis of many tumors. A paradigm is the activation of the __c‐myc__ gene by chromosomal translocations in Burkitt lymphoma (BL). Despite expression of a restricted set of Epstein–Barr viral (EBV) antigens, BL cells are not recognized by antigen‐specific cytotoxic T cells (CTLs) because of their inability to process and present HLA class I‐restricted antigens. In contrast, cells of EBV‐driven posttransplant lymphoproliferative disease (PTLD) are recognized and rejected by EBV‐specific CTLs. It is not known whether the poor immunogenicity of BL cells is due to nonexpression of viral antigens, overexpression of c‐myc, or both. To understand the basis for immune recognition and escape, we have compared the mRNA expression profiles of BL and EBV‐immortalized cells (as PTLD model). Among the genes expressed at low level in BL cells, we have identified many genes involved in the NF‐κB and interferon response that play a pivotal role in antigen presentation and immune recognition. Using a cell line in which EBNA2 and c‐myc can be regulated at will, we show that c‐MYC negatively regulates STAT1, the centra
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- Author
- Martin Schlee; Michael Hölzel; Sandra Bernard; Reinhard Mailhammer; Marino Schuhmacher; Judith Reschke; Dirk Eick; Dragan Marinkovic; Thomas Wirth; Andreas Rosenwald; Louis M. Staudt; Martin Eilers; Fanny Baran‐Marszak; Remi Fagard; Jean Feuillard; Gerhard Laux; Georg W. Bornkamm
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)