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Sensitivity of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. to the bactericidal action of LL-37: a cathelicidin found in human leukocytes and epithelium by D. Tanaka; K. T. Miyasaki; R. I. Lehrer is a Dentistry article available to read on EtoBox.
What is Sensitivity of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. to the bactericidal action of LL-37: a cathelicidin found in human leukocytes and epithelium about?
The bactericidal activity of synthetic LL‐37, a cathelicidin, was assessed against __Actinobacillus actinomycetemcomitans__ (three strains) and __Capnocytophaga__ spp. (three strains). All strains were sensitive to LL‐37, and exhibited 99% effective dose of 7.5‐to‐11.6 μg/ml. An amidated form of LL‐37, pentamide‐37, killed with about the same efficacy as LL‐37. Partial inhibition of killing was noted at physiologic concentrations of NaCl, and complete inhibition was observed at 400 mM NaCl. At approximately the 99% effective dose – i.e., 10 μg/ml – LL‐37 also lost activity against __A. actinomycetemcomitans__ in the presence of native or heat‐inactivated 10–15% normal human AB serum. Pentamide‐37 was less sensitive to serum inhibition than LL‐37. In conclusion, certain oral, gram‐negative bacteria are sensitive to the bactericidal activity of LL‐37 at low concentrations of serum and salt, a condition likely to be found within the membrane‐delimited phagolysosome. Modified forms of LL‐37, such as pentamide‐37, may be more suitable for future therapeutic application in the presence of serum.
Who reads Sensitivity of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. to the bactericidal action of LL-37: a cathelicidin found in human leukocytes and epithelium?
It is typically read by researchers, students, and practitioners in Dentistry.
- Author
- D. Tanaka; K. T. Miyasaki; R. I. Lehrer
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0902-0055)
- Published
- 2000
- Language
- EN
- Field
- Dentistry (Health Sciences)