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This document discusses the origination and evolution of the vertebrate limb skeleton from an epigenetic perspective. It proposes that the limb skeletal pattern emerges from complex interactions between genetic and non-genetic developmental mechanisms, rather than being strictly encoded by a genetic program. These epigenetic processes, such as self-organization of mesenchymal tissue, provide a basis for generating regularly spaced cartilage elements in the limb. The authors present a model involving core ce
- Author
- Eugenia Ramirez
- Language
- EN