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Astrocyte-derived Metallothionein Protects Dopaminergic Neurons from Dopamine Quinone Toxicity by Ikuko Miyazaki; Masato Asanuma; Yuri Kikkawa; Mika Takeshima; Shinki Murakami; Ko Miyoshi; Norio Sogawa; Taizo Kita is a Neuroscience article available to read on EtoBox.
What is Astrocyte-derived Metallothionein Protects Dopaminergic Neurons from Dopamine Quinone Toxicity about?
Our previous studies demonstrated the involvement of quinone formation in dopaminergic neuron dysfunction in the L-DOPA-treated parkinsonian model and in methamphetamine (METH) neurotoxicity. We further reported that the cysteine-rich metal-binding metallothionein (MT) family of proteins protects dopaminergic neurons against dopamine (DA) quinone neurotoxicity by its quinone-quenching property. The aim of this study was to examine MT induction in astrocytes in response to excess DA and the potential neuroprotective effects of astrocyte-derived MTs against DA quinone toxicity. DA exposure significantly upregulated MT-1/-2 in cultured striatal astrocytes, but not in mesencephalic neurons. This DA-induced MT upregulation in astrocytes was blocked by treatment with a DA-transporter (DAT) inhibitor, but not by DA-receptor antagonists. Expression of nuclear factor erythroid 2-related factor (Nrf2) and its binding activity to antioxidant response element of MT-1 gene were significantly increased in the astrocytes after DA exposure. Nuclear translocation of Nrf2 was suppressed by the DAT inhibitor. Quinone formation and reduction of mesencephalic DA neurons after DA exposure were ameliorat
Who reads Astrocyte-derived Metallothionein Protects Dopaminergic Neurons from Dopamine Quinone Toxicity?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Ikuko Miyazaki; Masato Asanuma; Yuri Kikkawa; Mika Takeshima; Shinki Murakami; Ko Miyoshi; Norio Sogawa; Taizo Kita
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2010
- Language
- EN
- Field
- Neuroscience (Life Sciences)