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Compressive force regulates ephrinB2 and EphB4 in osteoblasts and osteoclasts contributing to alveolar bone resorption during experimental tooth movement by Hou, Jianhua; Chen, Yanze; Meng, Xiuping; Shi, Ce; Li, Chen; Chen, Yuanping; Sun, Hongchen is a Dentistry article available to read on EtoBox.
What is Compressive force regulates ephrinB2 and EphB4 in osteoblasts and osteoclasts contributing to alveolar bone resorption during experimental tooth movement about?
## Objective To investigate the involvement of ephrinB2 in periodontal tissue remodeling in compression areas during orthodontic tooth movement and the effects of compressive force on EphB4 and ephrinB2 expression in osteoblasts and osteoclasts. ## Methods A rat model of experimental tooth movement was established to examine the histological changes and the localization of ephrinB2 in compressed periodontal tissues during experimental tooth movement. RAW264.7 cells and ST2 cells, used as precursor cells of osteoclasts and osteoblasts, respectively, were subjected to compressive force __in vitro__. The gene expression of EphB4 and ephrinB2, as well as bone-associated factors including Runx2, Sp7, NFATc1, and calcitonin receptor, were examined by quantitative real-time polymerase chain reaction (PCR). ## Results Histological examination of the compression areas of alveolar bone from experimental rats showed that osteoclastogenic activities were promoted while osteogenic activities were inhibited. Immunohistochemistry revealed that ephrinB2 was strongly expressed in osteoclasts in these areas. Quantitative real-time PCR showed that mRNA levels of NFATc1, calcitonin receptor, and ephri
Who reads Compressive force regulates ephrinB2 and EphB4 in osteoblasts and osteoclasts contributing to alveolar bone resorption during experimental tooth movement?
It is typically read by researchers, students, and practitioners in Dentistry.
- Author
- Hou, Jianhua; Chen, Yanze; Meng, Xiuping; Shi, Ce; Li, Chen; Chen, Yuanping; Sun, Hongchen
- Publisher
- Korean Association of Orthodontists (KAMJE); Korean Academy of Orthodonics; Korean Association of Orthodontists (ISSN 1225-5610)
- Published
- 2014
- Language
- EN
- Field
- Dentistry (Health Sciences)