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Can I read Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite on EtoBox?
Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite by Rena Nishizawa; Toshihiko Nishiyama; Katsuya Hisaichi; Naoki Matsunaga; Chiaki Minamoto; Hiromu Habashita; Yoshikazu Takaoka; Masaaki Toda; Shiro Shibayama; Hideaki Tada; Kenji Sagawa; Daikichi Fukushima; Kenji Maeda; Hiroaki Mitsuya is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite about?
Hydroxylated derivatives were designed and synthesized based on the information of oxidative metabolites. Compounds derived from b-substituted (2R,3R)-2-amino-3-hydroxypropionic acid showed improved inhibitory activities against the binding of MIP-1a to human CCR5, compared with the non-hydroxylated derivatives and the other isomers.
Who reads Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Rena Nishizawa; Toshihiko Nishiyama; Katsuya Hisaichi; Naoki Matsunaga; Chiaki Minamoto; Hiromu Habashita; Yoshikazu Takaoka; Masaaki Toda; Shiro Shibayama; Hideaki Tada; Kenji Sagawa; Daikichi Fukushima; Kenji Maeda; Hiroaki Mitsuya
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)