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Can I read In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines on EtoBox?
In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines by Judit Bartalis; Fathi T. Halaweish is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines about?
The aim of this study was to evaluate cucurbitacins (Cucs) liver protective activity in vitro and conduct QSAR studies against lipophilicity and ab initio descriptors. Nine Cucs were isolated from Cucurbitaceae plants and eight prepared by C2-alkylation or C16-acylation. Ten Cucs demonstrated protective activity on human hepatocyte-derived HepG2 cells exposed to CCl(4) (EC(50)=2.4-45.3 μM) with good margin to toxicity (T/A). All Cucs exhibited anti-proliferative effect on serum-activated rat stellate cells, HSC-T6 (EC(50)=0.02-4.12 μM) with high T/A. While silybin is nontoxic, its protection is lower compared to Cuc D (3), iso-D (4), I (5), B (11), E (12), I-Me (6), L-Me (7), and E-Me (13) on both cell lines. Strong correlations were found for lipophilicity with both protection and toxicity on HepG2. Lipophilicity correlated only with toxicity on HSC-T6. Consequently, we suggest that Cucs are potential hepatoprotective agents against fibrosis that deserve further examination.
Who reads In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Judit Bartalis; Fathi T. Halaweish
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)