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Mechanism of Modulation of Single Sodium Channels from Skeletal Muscle by the ? 1-Subunit from Rat Brain by Wolfgang Schreibmayer; Martin Wallner; Ilana Lotan is a Medicine article available to read on EtoBox.

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We studied the molecular mechanism of the rat skeletal muscle c~-subunit (c~ti) gating kinetics modulation by the brain 131-subunit by heterologous expression of single sodium channels from c~g I and 131 in Xenopus laevis oocytes. Coexpression of [31 reduced mean open time at -10 mV to ~21% when compared to channels expressed by ~gI alone. Channels formed by c~g I exerted multiple openings per depolarization, which occurred in bursts, in contrast to the channels formed by the c~.ti/131 complex that opened in average only once per depolarizing voltage pulse. Macroscopic current decay (mcd), as evidenced by reconstructed open probability vs. time (Po~,~), was greatly accelerated by 131, closely resembling mcd of sodium currents from native skeletal muscle. Generally p% was larger for channels expressed from the pure c~g I subunit. From our single channel data we conclude that 131 accelerates the inactivation process of the sodium channel complex.

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Author

Wolfgang Schreibmayer; Martin Wallner; Ilana Lotan

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0031-6768)

Published

1994

Language

EN

Field

Medicine (Life Sciences)