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Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice by Cong He; Zhen Yang; Dandan Cheng; Chuan Xie; Yin Zhu; Zhongming Ge; Zhijun Luo; Nonghua Lu is a Medicine article available to read on EtoBox.

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Emerging evidence suggests that __Helicobacter pylori__ infection is associated with insulin resistance (IR) yet the underlying mechanisms are still obscure. The vital role of gut microbiota in triggering IR has been increasingly reported, however, no study has explored the correlation of gut microbiota and __H. pylori__-associated IR. Using __H. pylori__-infected mice model fed different diet structures, we demonstrated that __H. pylori__ infection significantly aggravated high-fat diet (HFD)-induced metabolic disorders at the early stage, the extent of which was close to the effect of long-term HFD. Interestingly, we observed dynamic alterations in gut microbiota that were consistent with the changes in the metabolic phenotype induced by __H. pylori__ and HFD. There may be an interaction among __H. pylori__, diet and gut microbiota, which dysregulates the host metabolic homeostasis, and treatment of __H. pylori__ may be beneficial to the patients with impaired glucose tolerance in addition to diet control.

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Author

Cong He; Zhen Yang; Dandan Cheng; Chuan Xie; Yin Zhu; Zhongming Ge; Zhijun Luo; Nonghua Lu

Publisher

Elsevier BV

Published

2016

Language

EN

Field

Medicine (Life Sciences)