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The preoperative systemic inflammation response index (SIRI) independently predicts survival in postmenopausal women with breast cancer by Xin Hua; Zhi-Qing Long; Xin Huang; Jia-Peng Deng; Wen Wen; Zhen-Yu He; Ling Guo; Wen-Wen Zhang; Huan-Xin Lin is a Medicine article available to read on EtoBox.
What is The preoperative systemic inflammation response index (SIRI) independently predicts survival in postmenopausal women with breast cancer about?
The recently developed preoperative systemic inflammation response index (SIRI) was reported as a useful biomarker that could predict survival in certain types of malignant tumors. However, the prognostic value of preoperative SIRI in postmenopausal breast cancer remains unclear. This study aimed to explore the relationship between SIRI and survival in postmenopausal patients with breast cancer. A total of 390 postmenopausal patients with breast cancer who underwent a mastectomy at Sun Yat-sen University Cancer Center were retrospectively studied. SIRI was based on peripheral neutrophil, monocyte, and lymphocyte counts, calculated as: neutrophil count × monocyte count/lymphocyte count. The best cut-off value for SIRI was determined using receiver operating characteristic curve analysis. Patients were divided into 2 groups:Low SIRI 0.54. High SIRI was significantly related to progesterone receptor status. Kaplan-Meier survival analysis showed that T stage, N stage, clinical stage, carcinoembryonic antigen, estrogen receptor, progesterone receptor, endocrinotherapy, and SIRI were significantly correlated with overall survival (OS). Multivariate analysis showed that SIRI could also
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- Author
- Xin Hua; Zhi-Qing Long; Xin Huang; Jia-Peng Deng; Wen Wen; Zhen-Yu He; Ling Guo; Wen-Wen Zhang; Huan-Xin Lin
- Publisher
- Elsevier Science; Elsevier ; Mosby Inc.; Elsevier BV (ISSN 0147-0272)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)