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Endothelin system in oral squamous carcinoma cells: Specific siRNA targeting of ECE-1 blocks cell proliferation by Shuji Awano; Louise A. Dawson; Alison R. Hunter; Anthony J. Turner; Badar A. Usmani is a Medicine article available to read on EtoBox.
What is Endothelin system in oral squamous carcinoma cells: Specific siRNA targeting of ECE-1 blocks cell proliferation about?
## Abstract The present study focused on the endothelin axis in human oral squamous cell carcinoma (SCC) cells. We investigated the expression and distribution of endothelin‐1 (ET‐1), its receptors (endothelin‐A receptor (ET~A~R) and endothelin‐B receptor (ET~B~R)) and isoforms of its specific converting enzyme (ECE‐1a, 1b, 1c) and the report on their relative influences on cell proliferation. We also investigated the effect of an ECE‐specific inhibitor (ECE‐i) and siRNA targeting of the ECE‐1 gene on SCC cell proliferation. We observed the expression of ET‐1, ET~A~R, ET~B~R and all endothelin‐converting enzyme‐1 (ECE‐1) isoforms in oral SCC cells, but only the expression of ET‐1, ET~B~R and ECE‐1 was increased when compared to normal human epidermal keratinocytes. ET‐1 alone stimulated proliferation of oral SCC cells. Antagonists of either ET~A~R or ET~B~R inhibited ET‐1‐mediated proliferation. Decreased ECE‐1 expression after ECE siRNA treatment reduced SCC cell proliferation. Antiproliferative effects were also observed by inhibiting ECE activity with ECE‐i. In conclusion, the present study demonstrates that modulation of the endothelin system in oral SCC cells might provide a n
Who reads Endothelin system in oral squamous carcinoma cells: Specific siRNA targeting of ECE-1 blocks cell proliferation?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shuji Awano; Louise A. Dawson; Alison R. Hunter; Anthony J. Turner; Badar A. Usmani
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)