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Elevated sister chromatid exchange frequencies in dividing human peripheral blood lymphocytes exposed to 50 Hz magnetic fields by M.A. Wahab; J.V. Podd; B.I. Rapley; R.E. Rowland is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The in vitro cytomolecular technique, sister chromatid exchange (SCE), was applied to test the clastogenic potentiality of extremely low frequency (ELF) electromagnetic fields (EMFs) on human peripheral blood lymphocytes (HPBLs). SCE frequencies were scored in dividing peripheral blood lymphocytes (PBLs) from six healthy male blood donors in two rounds of experiments, R1 and R2, to determine reproducibility. Lymphocyte cultures in the eight experiments conducted in each round were exposed to 50 Hz sinusoidal (continuous or pulsed) or square (continuous or pulsed) MFs at field strengths of 1 μT or 1 mT for 72 h. A significant increase in the number of SCEs/cell in the grouped experimental conditions compared to the controls was observed in both rounds. The highest SCE frequency in R1 was 10.03 for a __square continuous__ field, and 10.39 for a __square continuous__ field was the second highest frequency in R2. DNA crosslinking at the replication fork is proposed as a model which could explain the mechanistic link between ELF EMF exposure and increased SCE frequency. Bioelectromagnetics 28:281–288, 2007. © 2006 Wiley‐Liss, Inc.

Who reads Elevated sister chromatid exchange frequencies in dividing human peripheral blood lymphocytes exposed to 50 Hz magnetic fields?

Author

M.A. Wahab; J.V. Podd; B.I. Rapley; R.E. Rowland

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0197-8462)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)