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Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt by Zhang, Jie-Lei; Zhang, Dian-Hong; Li, Ya-Peng; Wu, Lei-Ming; Liang, Cui; Yao, Rui; Wang, Zheng; Feng, Sheng-dong; Wang, Zhong-Min; Zhang, Yan-Zhou is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt about?
Cardiac hypertrophy (CH) is an independent risk factor for many cardiovascular diseases, and is one of the primary causes of morbidity and mortality in elderly people. Pathological CH involves excessive protein synthesis, increased cardiomyocyte size, and ultimately the development of heart failure. Myotubularin-related protein 14 (MTMR14) is a member of the myotubularin (MTM)-related protein family, which is involved in apoptosis, aging, inflammation, and autophagy. However, its exact function in CH is still unclear. Herein, we investigated the roles of MTMR14 in CH. We show that MTMR14 expression was increased in hypertrophic mouse hearts. Mice deficient in heart MTMR14 exhibited an aggravated aortic-banding (AB)-induced CH phenotype. In contrast, MTMR14 overexpression prevented pressure overload-induced hypertrophy. At the molecular level, prevention of CH in the absence of MTMR14 involved elevations in Akt pathway components, which are key elements that regulate apoptosis and cell proliferation. These results demonstrate that MTMR14 is a new molecular target for the treatment of CH.
Who reads Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zhang, Jie-Lei; Zhang, Dian-Hong; Li, Ya-Peng; Wu, Lei-Ming; Liang, Cui; Yao, Rui; Wang, Zheng; Feng, Sheng-dong; Wang, Zhong-Min; Zhang, Yan-Zhou
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC; London: Nature Publishing Group, 2001- (ISSN 2041-4889)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)