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Can I read The Rationale of Complement Blockade of the MCP~ggaac~ Haplotype following Atypical Hemolytic Uremic Syndrome of Three Southeastern European Countries with a Literature Review on EtoBox?
The Rationale of Complement Blockade of the MCP~ggaac~ Haplotype following Atypical Hemolytic Uremic Syndrome of Three Southeastern European Countries with a Literature Review by Daniel Turudic; Danka Pokrajac; Velibor Tasic; Dino Kasumovic; Zoltan Prohaszka; Danko Milosevic is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Rationale of Complement Blockade of the MCP~ggaac~ Haplotype following Atypical Hemolytic Uremic Syndrome of Three Southeastern European Countries with a Literature Review about?
We present eight cases of the homozygous MCPggaac haplotype, which is considered to increase the likelihood and severity of atypical hemolytic uremic syndrome (aHUS), especially in combination with additional risk aHUS mutations. Complement blockade (CBT) was applied at a median age of 92 months (IQR 36–252 months). The median number of relapses before CBT initiation (Eculizumab) was two. Relapses occurred within an average of 22.16 months (median 17.5, minimum 8 months, and maximum 48 months) from the first subsequent onset of the disease (6/8 patients). All cases were treated with PI/PEX, and rarely with renal replacement therapy (RRT). When complement blockade was applied, children had no further disease relapses. Children with MCPggaac haplotype with/without additional gene mutations can achieve remission through renal replacement therapy without an immediate need for complement blockade. If relapse of aHUS occurs soon after disease onset or relapses are repeated frequently, a permanent complement blockade is required. However, the duration of such a blockade remains uncertain. If complement inhibition is not applied within 4–5 relapses, proteinuria and chronic renal failure wi
Who reads The Rationale of Complement Blockade of the MCP~ggaac~ Haplotype following Atypical Hemolytic Uremic Syndrome of Three Southeastern European Countries with a Literature Review?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Daniel Turudic; Danka Pokrajac; Velibor Tasic; Dino Kasumovic; Zoltan Prohaszka; Danko Milosevic
- Publisher
- MDPI AG
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)