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This study investigates the cytotoxic effects of nickel ions (Ni3+) released from dental cast alloys on human gingival fibroblasts, revealing that Ni3+ inhibits cell proliferation and induces apoptosis. The IC50 value for Ni3+ was determined to be 389.6 µmol/l, with apoptosis linked to the activation of caspase-3. The findings highlight the need for further research into the mechanisms of toxicity associated with metal ions in dental materials.

Author

ena

Language

EN