Opening book details…
Can I read Outcome for Children <4 Years of Age with Malignant Central Nervous System Tumors Treated with High-dose Chemotherapy and Autologous Stem Cell Rescue on EtoBox?
Outcome for Children <4 Years of Age with Malignant Central Nervous System Tumors Treated with High-dose Chemotherapy and Autologous Stem Cell Rescue by Halldora K. Thorarinsdottir; Brian Rood; Naynesh Kamani; Debbie Lafond; Evelio Perez-Albuerne; Brett Loechelt; Roger J. Packer; Tobey J. MacDonald is a Medicine article available to read on EtoBox.
What is Outcome for Children <4 Years of Age with Malignant Central Nervous System Tumors Treated with High-dose Chemotherapy and Autologous Stem Cell Rescue about?
## Abstract ## Background Children <4 years of age (yo) with malignant central nervous system (CNS) tumors have a dismal prognosis. In an attempt to delay or obviate radiation therapy (XRT) and improve outcome, our institution has treated children <4 yo with newly diagnosed malignant CNS tumors with high‐dose chemotherapy (HDC) and autologous stem cell rescue (ASCR) followed by selective XRT. ## Procedure Fifteen children (age 4–38 months) with malignant CNS tumors have completed treatment with HDC/ASCR. All patients received three cycles of induction chemotherapy (cisplatin 3.5 mg/kg‐ day 0, cyclophosphamide 60 mg/kg‐ day 1 and 2, etoposide 2.5 mg/kg‐ day 0–2, vincristine 0.05 mg/kg, day 0, 7, 14) followed by three cycles of HDC (carboplatin 17 mg/kg and thiotepa 6 mg/kg, day 0 and 1) with ASCR. Histology included five medulloblastomas, four primitive neuroectodermal tumors (PNET), five malignant gliomas, and one ependymoma. Outcome and treatment toxicities were evaluated by retrospective chart review. ## Results Median follow‐up time of the 15 patients is 22 months (range 8–82 months). The 1‐ and 2‐year progression‐free survival (PFS) is 86.1% and 52.2% and overall survival (OS)
Who reads Outcome for Children <4 Years of Age with Malignant Central Nervous System Tumors Treated with High-dose Chemotherapy and Autologous Stem Cell Rescue?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Halldora K. Thorarinsdottir; Brian Rood; Naynesh Kamani; Debbie Lafond; Evelio Perez-Albuerne; Brett Loechelt; Roger J. Packer; Tobey J. MacDonald
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)