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Effects of Hysterectomy on Bone in Intact Rats, Ovariectomized Rats, and Ovariectomized Rats Treated with Estrogen by Dr. Ailsa Goulding; E. Gold; N. J. Lewis-Barned is a Medicine article available to read on EtoBox.

What is Effects of Hysterectomy on Bone in Intact Rats, Ovariectomized Rats, and Ovariectomized Rats Treated with Estrogen about?

To determine whether the uterus plays any role in mediating the ability of estrogen to conserve bone in the rat, eight groups of animals (n = 8) with their skeletons labeled with 45Ca were studied. Rats were ovariectomized (OVX), hysterectomized (Hyst), or given sham operations (Sham) and then pair-fed a low-hydroyproline casein diet for 4 weeks. The groups were treated orally with 17P-estradiol (E,) or vehicle, and serial measurements of biochemical markers of bone breakdown were made in weeks 1, 2, and 4. The femur density was measured by dual-energy X-ray absorptiometry (DXA), and skeletal calcium and 45Ca content were determined chemically. Final total body calcium values (mg) in the eight treatment groups were (means -C SD): Sham, 2573 2 179;

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Author

Dr. Ailsa Goulding; E. Gold; N. J. Lewis-Barned

Publisher

American Society for Bone and Mineral Research; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0884-0431)

Published

1996

Language

EN

Field

Medicine (Health Sciences)