Opening book details…
Can I read Effects of Hippeastrum reticulatum on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer’s disease on EtoBox?
Effects of Hippeastrum reticulatum on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer’s disease by Trang Huyen Xuan Hoang; Duc Viet Ho; Kiem Van Phan; Quan Van Le; Ain Raal; Hoai Thi Nguyen is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Effects of Hippeastrum reticulatum on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer’s disease about?
## Abstract ## Context The methanol extracts from __Hippeastrum reticulatum__ (L'Hér.) Herb. (Amaryllidaceae) (HR) display acetylcholinesterase inhibitory (AChEI) activity. ## Objective AChEI of alkaloids isolated from HR bulbs and the ameliorating effects of the alkaloid fraction (AHR) on memory and cognitive dysfunction in scopolamine-treated mice were investigated. ## Materials and methods Alkaloids were isolated by column chromatography and identified by spectroscopy. AChEI was evaluated using the modified Ellman’s method. Sixty Swiss male mice were randomly divided into six groups, received samples for 15 days. Normal group received saline, scopolamine-treated group scopolamine (1.5 mg/kg, intraperitoneal injection). Test groups received AHR (5, 10 and 15 mg/kg, per os) and positive control group donepezil (5 mg/kg, per os), administered 1 h before the test, scopolamine was injected 30 min prior to testing. The cognitive-enhancing activity of AHR against scopolamine-induced memory impairments was investigated using Y-maze, the novel object recognition test (NORT) and the Morris water maze (MWM) test. ## Results Seven alkaloids were isolated for the first time from the genus __
Who reads Effects of Hippeastrum reticulatum on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer’s disease?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Trang Huyen Xuan Hoang; Duc Viet Ho; Kiem Van Phan; Quan Van Le; Ain Raal; Hoai Thi Nguyen
- Published
- 2020
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)