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Can I read The U-box ubiquitin ligase TUD1 promotes brassinosteroid-induced GSK2 degradation in rice on EtoBox?
The U-box ubiquitin ligase TUD1 promotes brassinosteroid-induced GSK2 degradation in rice by Dapu Liu; Xiaoxing Zhang; Qingliang Li; Yunhua Xiao; Guoxia Zhang; Wenchao Yin; Mei Niu; Wenjing Meng; Nana Dong; Jihong Liu; Yanzhao Yang; Qi Xie; Chengcai Chu; Hongning Tong is a Agricultural and Biological Sciences article available to read on EtoBox.
What is The U-box ubiquitin ligase TUD1 promotes brassinosteroid-induced GSK2 degradation in rice about?
Brassinosteroids (BRs) are a class of steroid hormones with great potential for use in crop improvement. De-repression is usually one of the key events in hormone signaling. However, how the stability of GSK2, the central negative regulator of BR signaling in rice (__Oryza sativa__), is regulated by BRs remains elusive. Here, we identify the U-box ubiquitin ligase TUD1 as a GSK2-interacting protein by yeast two-hybrid screening. We show that TUD1 is able to directly interact with GSK2 and ubiquitinate the protein. Phenotypes of the __tud1__ mutant are highly similar to those of plants with constitutively activated GSK2. Consistent with this finding, GSK2 protein accumulates in the __tud1__ mutant compared with the wild type. In addition, inhibition of BR synthesis promotes GSK2 accumulation and suppresses TUD1 stability. By contrast, BRs can induce GSK2 degradation but promote TUD1 accumulation. Furthermore, the GSK2 degradation process is largely impaired in __tud1__ in response to BR. In conclusion, our study demonstrates the role of TUD1 in BR-induced GSK2 degradation, thereby advancing our understanding of a critical step in the BR signaling pathway of rice.
Who reads The U-box ubiquitin ligase TUD1 promotes brassinosteroid-induced GSK2 degradation in rice?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Dapu Liu; Xiaoxing Zhang; Qingliang Li; Yunhua Xiao; Guoxia Zhang; Wenchao Yin; Mei Niu; Wenjing Meng; Nana Dong; Jihong Liu; Yanzhao Yang; Qi Xie; Chengcai Chu; Hongning Tong
- Publisher
- Elsevier
- Published
- 2022
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)