Can I read Suitability of Using Serum Hialuronic Acid Concentrations in the Diagnosis of Canine Liver Fibrosis on EtoBox?

Suitability of Using Serum Hialuronic Acid Concentrations in the Diagnosis of Canine Liver Fibrosis by K. Glińska-Suchocka; A. Orłowska; J. Spużak; M. Jankowski; K. Kubiak is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Suitability of Using Serum Hialuronic Acid Concentrations in the Diagnosis of Canine Liver Fibrosis about?

## Abstract There are multiple dynamic changes associated with the metabolism of the extracellular matrix (ECM) which occur in the course of liver fibrosis. Therefore, the evaluation of parameters reflecting the deposition of ECM, the activity of myofibroblasts and the synthesis and degradation of collagen may aid in the diagnosis of liver fibrosis. Hyaluronic acid is considered to be a marker of ECM deposition. It is a glycosaminoglycan synthesized by hepatic stellate cells and degraded by hepatic sinusoidal endothelial cells. The aim of this study was to evaluate the concentration of hyaluronic acid in dogs with different degrees of liver fibrosis. The study was carried out on 29 dogs with liver disease. A core needle biopsy of the liver was performed in order to assess the degree of hepatic inflammation. Then, hyaluronic acid serum concentrations were measured. The dogs were divided into five groups based on the histopathological examination and the evaluation of the degree of hepatic fibrosis. The study showed that serum hyaluronic acid concentrations were low in patients with first stage liver fibrosis and in controls, while they were twice as high as control values in the gro

Who reads Suitability of Using Serum Hialuronic Acid Concentrations in the Diagnosis of Canine Liver Fibrosis?

Author

K. Glińska-Suchocka; A. Orłowska; J. Spużak; M. Jankowski; K. Kubiak

Publisher

Walter de Gruyter GmbH

Published

2016

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)