Opening book details…
Can I read Multifocal Skull-compensated Transcranial Focused Ultrasound System for Neuromodulation Applications Based on Acoustic Holography on EtoBox?
Multifocal Skull-compensated Transcranial Focused Ultrasound System for Neuromodulation Applications Based on Acoustic Holography by Geon Kook; Yehhyun Jo; Chaerin Oh; Xiaojia Liang; Jaewon Kim; Sang-Mok Lee; Subeen Kim; Jung-Woo Choi; Hyunjoo Jenny Lee is a Engineering article available to read on EtoBox.
What is Multifocal Skull-compensated Transcranial Focused Ultrasound System for Neuromodulation Applications Based on Acoustic Holography about?
Transcranial focused ultrasound stimulation is a promising therapeutic modality for human brain disorders because of its noninvasiveness, long penetration depth, and versatile spatial control capability through beamforming and beam steering. However, the skull presents a major hurdle for successful applications of ultrasound stimulation. Specifically, skull-induced focal aberration limits the capability for accurate and versatile targeting of brain subregions. In addition, there lacks a fully functional preclinical neuromodulation system suitable to conduct behavioral studies. Here, we report a miniature ultrasound system for neuromodulation applications that is capable of highly accurate multiregion targeting based on acoustic holography. Our work includes the design and implementation of an acoustic lens for targeting brain regions with compensation for skull aberration through time-reversal recording and a phase conjugation mirror. Moreover, we utilize MEMS and 3D-printing technology to implement a 0.75-g lightweight neuromodulation system and present in vivo characterization of the packaged system in freely moving mice. This preclinical system is capable of accurately targeting
Who reads Multifocal Skull-compensated Transcranial Focused Ultrasound System for Neuromodulation Applications Based on Acoustic Holography?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Geon Kook; Yehhyun Jo; Chaerin Oh; Xiaojia Liang; Jaewon Kim; Sang-Mok Lee; Subeen Kim; Jung-Woo Choi; Hyunjoo Jenny Lee
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)