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Can I read Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae on EtoBox?
Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae by Yu, Xiaoqin; MÃ1⁄4ller, Werner E. G.; Meier, Dieter; Kalscheuer, Rainer; Guo, Zhiyong; Zou, Kun; Umeokoli, Blessing O.; Liu, Zhen; Proksch, Peter is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae about?
Chemical investigation of secondary metabolites from the endophytic fungus __Pseudopestalotiopsis theae__ led to the isolation of eighteen new polyketide derivatives, pestalotheols I–Q (**1**–**9**) and cytosporins O–W (**15**–**23**), together with eight known analogs (**10**–**14** and **24**–**26**). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher’s method was applied to determine the absolute configuration of some compounds. Compound **23** showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with an IC~50~ value of 3.0 μM. Furthermore, compounds **22** and **23** showed moderate antibacterial activity against drug-resistant __Acinetobacter baumannii__ (ATCC BAA-1605) in combination with sublethal colistin concentrations.
Who reads Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yu, Xiaoqin; MÃ1⁄4ller, Werner E. G.; Meier, Dieter; Kalscheuer, Rainer; Guo, Zhiyong; Zou, Kun; Umeokoli, Blessing O.; Liu, Zhen; Proksch, Peter
- Publisher
- MDPI Publishing; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI, 2003- (ISSN 1660-3397)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)