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Protection of Lassa Virus-infected Guinea Pigs with Lassa-immune Plasma of Guinea Pig, Primate, and Human Origin by Dr P. B. Jahrling is a Medicine article available to read on EtoBox.

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Lassa virus-immune plasma has been used to treat human Lassa fever patients; however, criteria for plasma selection were based arbitrarily on available serologic tools and protective efficacy was never directly assessed. To test the validity of plasma therapy for Lassa virus infections in an animal model, and to develop biologically relevant criteria for selection of protective immune plasma, inbred, strain 13 guinea pigs were infected with a lethal dose of Lassa virus and treated with various Lassa-immune plasmas obtained from guinea pigs, primates, and convalescent human patients. Neutralizing antibody titers were determined in a virus dilution, plaque reduction test, and were expressed as a loglo plaque-forming units (PFU) neutralization index (LNI). All guinea pigs treated with immune plasma 6 mlikgltreatment on days 0. 3, and 6 after virus inoculation were protected, provided the LNI exceeded 2.0. Plasmas obtained from donors in early convalescence (32-45 days) had low titers of N-antibody (LNI < 2 ) and failed to confer protection, despite high titers of Lassa antibody measurcd in the indirect fluorescent antibody (IFA) test. Higher doses of marginally titered plasma conferre

Who reads Protection of Lassa Virus-infected Guinea Pigs with Lassa-immune Plasma of Guinea Pig, Primate, and Human Origin?

Author

Dr P. B. Jahrling

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

1983

Language

EN

Field

Medicine (Health Sciences)