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Tanshinone IIA Suppresses Proliferation and Inflammatory Cytokine Production of Synovial Fibroblasts from Rheumatoid Arthritis Patients Induced by TNF-α and Attenuates the Inflammatory Response in AIA Mice by Du, Hongyan ;Wang, Yuechun ;Zeng, Yongchang ;Huang, Xiaoming ;Liu, Dingfei ;Ye, Lvlan ;Li, Yang ;Chen, Xiaochen ;Liu, Tiancai ;Li, Hongwei ;Wu, Jing ;Yu, Qinghong ;Wu, Yingsong ;Jie, Ligang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease in which activated RA fibroblast-1ike synoviocytes (RA-FLSs) are one of the main factors responsible for inducing morbidity. Previous reports have shown that RA-FLSs have proliferative features similar to cancer cells, in addition to causing cartilage erosion that eventually causes joint damage. Thus, new therapeutic strategies and drugs that can effectively contain the abnormal hyperplasia of RA-FLSs and restrain RA development are necessary for the treatment of RA. Tanshinone IIA (Tan IIA), one of the main phytochemicals isolated from __Salvia miltiorrhiza__ Bunge, is capable of promoting RA-FLS apoptosis and inhibiting arthritis in an AIA mouse model. In addition, RA patients treated at our clinic with Tan IIA showed significant improvements in their clinical symptoms. However, the details of the molecular mechanism by which Tan IIA effects RA are unknown. To clarify this mechanism, we evaluated the antiproliferative and inhibitory effects of proinflammatory factor production caused by Tan IIA to RA-FLSs. We demonstrated that Tan IIA can restrict the proliferation, migration, and invasion of RA-FLSs in a t

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Author

Du, Hongyan ;Wang, Yuechun ;Zeng, Yongchang ;Huang, Xiaoming ;Liu, Dingfei ;Ye, Lvlan ;Li, Yang ;Chen, Xiaochen ;Liu, Tiancai ;Li, Hongwei ;Wu, Jing ;Yu, Qinghong ;Wu, Yingsong ;Jie, Ligang

Publisher

Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2010- (ISSN 1663-9812)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)